梅红
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医生介绍
梅红 简历
华中科技大学同济医学院附属协和医院，主治医师、讲师。
主要从事小儿各种泌尿生殖系畸形的微创手术及肿瘤的综合治疗，如先天性肾积水、输尿管囊肿、输尿管开口异位、膀胱输尿管反流、尿失禁、先天性尿道下裂、尿道上裂、尿道外伤、隐匿性阴茎、隐睾症、两性畸形、小儿泌尿系结石、肾母细胞瘤、神经母细胞瘤等疾病。
主持国家自然科学基金面上项目1项，国家自然科学基金青年科学基金1项，华中科技大学自主创新基金1项，在《Oncogene》、《Mol Cancer Ther》、《Mol Cancer Res》等国际期刊发表SCI论文30余篇，主译《小儿泌尿外科腔镜手术学》、《小儿机器人及重建泌尿外科学(综合指南)》。
1、教育经历
· 2010/09 – 2013/06 华中科技大学同济医学院外科学，医学博士，导师：童强松
· 2003/09 – 2010/06 华中科技大学同济医学院，医学硕士(七年制)，导师：童强松
2、科研与学术工作经历
· 2013/12 – 至今 华中科技大学同济医学院附属协和医院，主治医师、讲师
· 2012/12 – 2013/12 美国阿肯色大学医学院，访问学者
· 2010/09 – 2012/08 华中科技大学同济医学院附属协和医院，住院医师
3、代表性研究成果和学术奖励情况
· 期刊论文 (# 第一作者、* 通讯作者)：
· 第一作者论文
(1) Li D (#), Chen Y (#), Mei H (#), Jiao W, Song H, Ye L, Fang E, Wang X, Yang F, Huang K, Zheng L(*), Tong Q(*). Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression. Oncogene. 2018 May 18. doi: 10.1038/s41388-018-0302-4.
(2) Mei H (#), Zhao X, Li D, Fang E, Wang X, Song H, Pu J, Zheng L, Tong Q(*). Comparison of transumbilical multiport and standard laparoscopic pyeloplasty in children: Mid-term results at a single center. J Pediatr Surg. 2017 Mar;52(3):473-477. doi: 10.1016/j.jpedsurg.2016.08.013.
(3) Zheng L (#), Jiao W (#), Mei H (#), Song H, Li D, Xiang X, Chen Y, Yang F, Li H, Huang K, Tong Q (*). miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14. Oncotarget, 2016, 7(26): 40314-40328.
(4) Mei H (#), Lin Z, Tong Q (*). Risk stratification and therapeutics of neuroblastoma: the challenges remain. World J Pediatr, 2016, 12(1): 5-7.
(5) Mei H (#), Wang Y, Fan J, Lin Z (*). Alternative splicing of S6K1 promotes non-small cell lung cancer survival. Tumour Biol, 2016, 37(10): 13369-13376.
(6) Xiang X (#), Mei H (#), Qu H, Zhao X, Li D, Song H, Jiao W, Pu J, Huang K, Zheng L (*), Tong Q (*). miRNA-584-5p exerts tumor suppressive functions in human neuroblastoma through repressing transcription of matrix metalloproteinase 14. Biochim Biophys Acta, 2015, 1852(9): 1743-1754.
(7) Xiang X (#), Mei H (#), Zhao X (#), Pu J, Li D, Qu H, Jiao W, Zhao J, Huang K, Zheng L (*), Tong Q (*). miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14. Oncotarget, 2015, 6(26): 22452-22466.
(8) Li D (#), Mei H (#), Pu J (#), Xiang X, Zhao X, Qu H, Huang K, Zheng L (*), Tong Q (*). Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2. Mol Cancer, 2015, 14: 47.
(9) Mei H (#), Lin Z (#), Tong Q (*). The roles of microRNAs in neuroblastoma. World J Pediatr, 2014, 10(1): 10-16.
(10) Mei H (#), Lin Z (#), Wang Y, Wu G, Song Y (*). Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer. Neoplasma, 2014, 61(2): 186-192.
(11) Mei H (#), Wang Y, Lin Z (*), Tong Q. The mTOR signaling pathway in pediatric neuroblastoma. Pediatr Hematol Oncol, 2013, 30(7): 605-615.
(12) Li D (#), Mei H (#), Qi M (#), Yang D, Zhao X, Xiang X, Pu J, Huang K, Zheng L (*), Tong Q (*). FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma. Oncotarget, 2013, 4(11): 2021-2044.
(13) Mei H (#), Qi T, Li S, Pu J, Cao G, Tang S, Zheng L, Tong Q(*). Transumbilical multiport laparoscopic nephroureterectomy for congenital renal dysplasia in children: midterm follow-up from a single institution. Front Pediatr. 2013 Dec 13;1:46. doi: 10.3389/fped.2013.00046. eCollection 2013.
(14) Mei H(#), Pu J, Qi T, Qi M, Li D, Tang S, Zheng L, Tong Q(*). Transumbilical multiport laparoscopic orchiopexy in children: comparison with standard laparoscopic orchiopexy. Urology. 2012 Dec;80(6):1345-9. doi: 10.1016 /j.urology.2012.07.076.
(15) Mei H(#), Pu J, Yang C, Zhang H, Zheng L, Tong Q(*). Laparoscopic versus open pyeloplasty for ureteropelvic junction obstruction in children: a systematic review and meta-analysis. J Endourol. 2011 May;25(5):727-36. doi: 10.1089/end.2010.0544. Epub 2011 Apr 8.
(16) Mei H(#), Zheng L, Zhou C, Tong Q(*). Metanephric adenoma in a 2-year-old child: case report and immunohistochemical observations. J Pediatr Hematol Oncol. 2010 Aug;32(6):489-93. doi: 10.1097/MPH.0b013e3181e34de1.
· 既非第一作者又非通讯作者论文
(1) Zheng L (#), Jiao W (#), Song H, Qu H, Li D, Mei H, Chen Y, Yang F, Li H, Huang K, Tong Q (*). miRNA-558 promotes gastric cancer progression through attenuating Smad4-mediated repression of heparanase expression. Cell Death Dis, 2016, 7: e2382.
(2) Li D (#), Wang X (#), Mei H, Fang E, Ye L, Song H, Yang F, Li H, Huang K, Zheng L, Tong Q(*). Long Noncoding RNA pancEts-1 Promotes Neuroblastoma Progression through hnRNPK-Mediated β-Catenin Stabilization. Cancer Res. 2018 Mar 1;78(5):1169-1183. doi: 10.1158/0008- 5472.CAN-17-2295.
(3) Qu H (#), Zheng L (#), Jiao W (#), Mei H, Li D, Song H, Fang E, Wang X, Li S, Huang K, Tong Q (*). Smad4 suppresses the tumorigenesis and aggressiveness of neuroblastoma through repressing the expression of heparanase. Sci Rep, 2016, 6: 32628.
(4) Qu H (#), Zheng L (#), Song H, Jiao W, Li D, Fang E, Wang X, Mei H, Pu J, Huang K, Tong Q (*). microRNA-558 facilitates the expression of hypoxia-inducible factor 2 alpha through binding to 5'-untranslated region in neuroblastoma. Oncotarget, 2016, 7(26): 40657-40673.
(5) Zhao X (#), Li D (#), Pu J, Mei H, Yang D, Xiang X, Qu H, Huang K (#), Zheng L (*), Tong Q (*). CTCF cooperates with non-coding RNA MYCNOS to promote neuroblastoma progression through facilitating MYCN expression. Oncogene, 2016, 35(27):3565-3576.
(6) Li D (#), Zhao X (#), Xiao Y (#), Mei H, Pu J, Xiang X, Jiao W, Song H, Qu H, Huang K, Zheng L (*), Tong Q (*). Intelectin 1 suppresses tumor progression and is associated with improved survival in gastric cancer. Oncotarget, 2015, 6(18): 16168-16182.
(7) Qu H (#), Zheng L (#), Pu J (#), Mei H, Xiang X, Zhao X, Li D, Li S, Mao L, Huang K, Tong Q (*). miRNA-558 promotes tumorigenesis and aggressiveness of neuroblastoma cells through activating the transcription of heparanase. Human Mol Genet, 2015, 24(9): 2539-2551.
(8) Xiang X (#), Zhao X (#), Qu H (#), Li D, Yang D, Pu J, Mei H, Zhao J, Huang K, Zheng L (*), Tong Q (*). Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14. Cancer Lett, 2015, 359(2): 187-197.
(9) Zhang H (#), Qi M (#), Li S (#), Qi T, Mei H, Huang K, Zheng L (*), Tong Q (*). microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis and angiogenesis of neuroblastoma cells. Mol Cancer Ther, 2012, 11(7): 1454–1466.
(10) Jiang G (#), Zheng L (#), Pu J, Mei H, Zhao J, Huang K, Zeng F (*), Tong Q (*). Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells. PLoS One, 2012, 7(2): e31379.
华中科技大学同济医学院附属协和医院，主治医师、讲师。
主要从事小儿各种泌尿生殖系畸形的微创手术及肿瘤的综合治疗，如先天性肾积水、输尿管囊肿、输尿管开口异位、膀胱输尿管反流、尿失禁、先天性尿道下裂、尿道上裂、尿道外伤、隐匿性阴茎、隐睾症、两性畸形、小儿泌尿系结石、肾母细胞瘤、神经母细胞瘤等疾病。
主持国家自然科学基金面上项目1项，国家自然科学基金青年科学基金1项，华中科技大学自主创新基金1项，在《Oncogene》、《Mol Cancer Ther》、《Mol Cancer Res》等国际期刊发表SCI论文30余篇，主译《小儿泌尿外科腔镜手术学》、《小儿机器人及重建泌尿外科学(综合指南)》。
1、教育经历
· 2010/09 – 2013/06 华中科技大学同济医学院外科学，医学博士，导师：童强松
· 2003/09 – 2010/06 华中科技大学同济医学院，医学硕士(七年制)，导师：童强松
2、科研与学术工作经历
· 2013/12 – 至今 华中科技大学同济医学院附属协和医院，主治医师、讲师
· 2012/12 – 2013/12 美国阿肯色大学医学院，访问学者
· 2010/09 – 2012/08 华中科技大学同济医学院附属协和医院，住院医师
3、代表性研究成果和学术奖励情况
· 期刊论文 (# 第一作者、* 通讯作者)：
· 第一作者论文
(1) Li D (#), Chen Y (#), Mei H (#), Jiao W, Song H, Ye L, Fang E, Wang X, Yang F, Huang K, Zheng L(*), Tong Q(*). Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression. Oncogene. 2018 May 18. doi: 10.1038/s41388-018-0302-4.
(2) Mei H (#), Zhao X, Li D, Fang E, Wang X, Song H, Pu J, Zheng L, Tong Q(*). Comparison of transumbilical multiport and standard laparoscopic pyeloplasty in children: Mid-term results at a single center. J Pediatr Surg. 2017 Mar;52(3):473-477. doi: 10.1016/j.jpedsurg.2016.08.013.
(3) Zheng L (#), Jiao W (#), Mei H (#), Song H, Li D, Xiang X, Chen Y, Yang F, Li H, Huang K, Tong Q (*). miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14. Oncotarget, 2016, 7(26): 40314-40328.
(4) Mei H (#), Lin Z, Tong Q (*). Risk stratification and therapeutics of neuroblastoma: the challenges remain. World J Pediatr, 2016, 12(1): 5-7.
(5) Mei H (#), Wang Y, Fan J, Lin Z (*). Alternative splicing of S6K1 promotes non-small cell lung cancer survival. Tumour Biol, 2016, 37(10): 13369-13376.
(6) Xiang X (#), Mei H (#), Qu H, Zhao X, Li D, Song H, Jiao W, Pu J, Huang K, Zheng L (*), Tong Q (*). miRNA-584-5p exerts tumor suppressive functions in human neuroblastoma through repressing transcription of matrix metalloproteinase 14. Biochim Biophys Acta, 2015, 1852(9): 1743-1754.
(7) Xiang X (#), Mei H (#), Zhao X (#), Pu J, Li D, Qu H, Jiao W, Zhao J, Huang K, Zheng L (*), Tong Q (*). miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14. Oncotarget, 2015, 6(26): 22452-22466.
(8) Li D (#), Mei H (#), Pu J (#), Xiang X, Zhao X, Qu H, Huang K, Zheng L (*), Tong Q (*). Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2. Mol Cancer, 2015, 14: 47.
(9) Mei H (#), Lin Z (#), Tong Q (*). The roles of microRNAs in neuroblastoma. World J Pediatr, 2014, 10(1): 10-16.
(10) Mei H (#), Lin Z (#), Wang Y, Wu G, Song Y (*). Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer. Neoplasma, 2014, 61(2): 186-192.
(11) Mei H (#), Wang Y, Lin Z (*), Tong Q. The mTOR signaling pathway in pediatric neuroblastoma. Pediatr Hematol Oncol, 2013, 30(7): 605-615.
(12) Li D (#), Mei H (#), Qi M (#), Yang D, Zhao X, Xiang X, Pu J, Huang K, Zheng L (*), Tong Q (*). FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma. Oncotarget, 2013, 4(11): 2021-2044.
(13) Mei H (#), Qi T, Li S, Pu J, Cao G, Tang S, Zheng L, Tong Q(*). Transumbilical multiport laparoscopic nephroureterectomy for congenital renal dysplasia in children: midterm follow-up from a single institution. Front Pediatr. 2013 Dec 13;1:46. doi: 10.3389/fped.2013.00046. eCollection 2013.
(14) Mei H(#), Pu J, Qi T, Qi M, Li D, Tang S, Zheng L, Tong Q(*). Transumbilical multiport laparoscopic orchiopexy in children: comparison with standard laparoscopic orchiopexy. Urology. 2012 Dec;80(6):1345-9. doi: 10.1016 /j.urology.2012.07.076.
(15) Mei H(#), Pu J, Yang C, Zhang H, Zheng L, Tong Q(*). Laparoscopic versus open pyeloplasty for ureteropelvic junction obstruction in children: a systematic review and meta-analysis. J Endourol. 2011 May;25(5):727-36. doi: 10.1089/end.2010.0544. Epub 2011 Apr 8.
(16) Mei H(#), Zheng L, Zhou C, Tong Q(*). Metanephric adenoma in a 2-year-old child: case report and immunohistochemical observations. J Pediatr Hematol Oncol. 2010 Aug;32(6):489-93. doi: 10.1097/MPH.0b013e3181e34de1.
· 既非第一作者又非通讯作者论文
(1) Zheng L (#), Jiao W (#), Song H, Qu H, Li D, Mei H, Chen Y, Yang F, Li H, Huang K, Tong Q (*). miRNA-558 promotes gastric cancer progression through attenuating Smad4-mediated repression of heparanase expression. Cell Death Dis, 2016, 7: e2382.
(2) Li D (#), Wang X (#), Mei H, Fang E, Ye L, Song H, Yang F, Li H, Huang K, Zheng L, Tong Q(*). Long Noncoding RNA pancEts-1 Promotes Neuroblastoma Progression through hnRNPK-Mediated β-Catenin Stabilization. Cancer Res. 2018 Mar 1;78(5):1169-1183. doi: 10.1158/0008- 5472.CAN-17-2295.
(3) Qu H (#), Zheng L (#), Jiao W (#), Mei H, Li D, Song H, Fang E, Wang X, Li S, Huang K, Tong Q (*). Smad4 suppresses the tumorigenesis and aggressiveness of neuroblastoma through repressing the expression of heparanase. Sci Rep, 2016, 6: 32628.
(4) Qu H (#), Zheng L (#), Song H, Jiao W, Li D, Fang E, Wang X, Mei H, Pu J, Huang K, Tong Q (*). microRNA-558 facilitates the expression of hypoxia-inducible factor 2 alpha through binding to 5'-untranslated region in neuroblastoma. Oncotarget, 2016, 7(26): 40657-40673.
(5) Zhao X (#), Li D (#), Pu J, Mei H, Yang D, Xiang X, Qu H, Huang K (#), Zheng L (*), Tong Q (*). CTCF cooperates with non-coding RNA MYCNOS to promote neuroblastoma progression through facilitating MYCN expression. Oncogene, 2016, 35(27):3565-3576.
(6) Li D (#), Zhao X (#), Xiao Y (#), Mei H, Pu J, Xiang X, Jiao W, Song H, Qu H, Huang K, Zheng L (*), Tong Q (*). Intelectin 1 suppresses tumor progression and is associated with improved survival in gastric cancer. Oncotarget, 2015, 6(18): 16168-16182.
(7) Qu H (#), Zheng L (#), Pu J (#), Mei H, Xiang X, Zhao X, Li D, Li S, Mao L, Huang K, Tong Q (*). miRNA-558 promotes tumorigenesis and aggressiveness of neuroblastoma cells through activating the transcription of heparanase. Human Mol Genet, 2015, 24(9): 2539-2551.
(8) Xiang X (#), Zhao X (#), Qu H (#), Li D, Yang D, Pu J, Mei H, Zhao J, Huang K, Zheng L (*), Tong Q (*). Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14. Cancer Lett, 2015, 359(2): 187-197.
(9) Zhang H (#), Qi M (#), Li S (#), Qi T, Mei H, Huang K, Zheng L (*), Tong Q (*). microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis and angiogenesis of neuroblastoma cells. Mol Cancer Ther, 2012, 11(7): 1454–1466.
(10) Jiang G (#), Zheng L (#), Pu J, Mei H, Zhao J, Huang K, Zeng F (*), Tong Q (*). Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells. PLoS One, 2012, 7(2): e31379.
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